The greater geometric lability of hydrazones over oxime ethers is used as a basis to overcome the reluctance of Zoxime ether azatrienes to undergo electrocyclization towards the synthesis of borylated (heteroaromatic) pyridines and ring-fused analogs. Such hydrazones now allow access to previously inaccessible tri-and tetrasubstituted 3-borylpyridines in high yields.The prominence of heteroaromatic motifs in pharmaceutical agents, agrochemicals and functional materials has motivated synthetic chemists to devise new strategies for the efficient and selective incorporation of these fragments into a broad range of molecular scaffolds. In this regard, boronic acid chemistry provides one of the most widely used approaches Scheme 1. Dependence of electrocyclization efficiency on oxime ether stereochemistry for the coupling of heteroaromatic systems because of the synthetic versatility of these compounds. 1
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