Plasma samples from haemodialysis patients, renal allograft recipients and
haemophiliacs were studied for the presence of mixed leukocyte culture blocking factor
activity (BFA). A history of blood transfusions received within the preceding 6 months
of testing was significantly and directly correlated with the appearance and persistence of
BFA in the plasma of haemodialysis patients. This association was not found in renal
allograft recipients. The development of BFA was found to be associated with formation
of lymphocytotoxins but not haemagglutinins. The authors have also demonstrated that
BFA resides in the IgG fractions of serum samples obtained from both chronic uraemics
undergoing haemodialysis and patients bearing renal allografts. BFA may play a minor
role in the acceptance of human renal allografts.
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