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SummaryAmiloride hydrochloride is a very potent drug for correcting the profound hypokalaemia and metabolic alkalosis that is induced by thiazide and other diuretics. No potassium supplements are necessary.

Summary Two hundred and twenty-seven cases of moderate to severe hypertension were treated with thiazide diuretics alone for periods of up to 12 years. In 80% the hypertension was adequately controlled without additional antihypertensive agents. Hypokalaemic alkalosis was common despite potassium supplements—but caused no symptoms. The incidence of diabetes and gout was low. It is concluded that thiazide diuretics provide excellent control of hypertension with very few side effects.

SummaryThe incidence of stroke in a group of 499 treated hypertensive patients was closely related to the adequacy of control of hypertension. This trend was independent of the level of diastolic blood pressure at presentation, and differed markedly from the incidence of myocardial infarction and angina pectoris which did not vary with adequacy of control.