We performed a prospective multicentre study to evaluate the efficacy of therapeutic strategies currently used for ocular toxoplasmosis in a large number of patients (n = 106). Treatment was given for at least four weeks and consisted of three triple drug combinations: group 1, pyrimethamine, sulphadiazine and corticosteroids (n = 29); group 2. clindamycin, sulphadiazine and corticosteroids (n = 37); and group 3. cotrimoxazole (trimethoprim and sulphamethoxazole) and corticosteroids (n = 8). Patients with peripheral retinal lesions remained without systemic therapy (group 4, n = 32). Patients from group 1 received leucovorin 5 mg twice a week. No difference in the duration of inflammatory activity was observed between the treated and untreated patients or between the separate groups of patients. The most important factor predicting the duration of inflammatory activity was the size of the retinal focus itself, independently of the therapy given (P less than 0.05). We showed a reduction in size of the retinal inflammatory focus in 52% of the pyrimethamine patients as compared to 25% of untreated cases. However the most frequent side effects were also associated with pyrimethamine medication and included hematologic complications as thrombocytopenia and leucopenia despite leucovorin medication.
The data of 750 consecutive uveitis patients who visited the uveitis department of the Rotterdam Eye Hospital were analysed by computer. Anterior uveitis was diagnosed most frequently (52%), mostly the acute form. We found a high percentage of Fuchs' heterochromic iridocyclitis and HLA-B27+ iridocyclitis. In the posterior uveitis group appeared the more recent clinical entities such as acute retinal necrosis, Birdshot retinochoroidopathy, CMV-retinitis, AMPPE and ocular candidiasis. Ocular Toxoplasmosis was still the leading cause in this group. These data will be compared with other studies of similar populations. Factors influencing frequency of subtypes of uveitis and bias of this study will be discussed.
Die Raman‐Spektren von MoO3/Al2O3‐Katalysatoren mit 3‐25 Gew.‐% MoO3 werden vom H2O‐Gehalt der Proben dramatisch beeinflußt. In O2 bei 500°C calcinierte Katalysatoren zeigen Spektren, die sich von früher veröffentlichten stark unterscheiden.
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