Carboxylic acid esters
Carboxylic acid esters Q 0530Synthesis and Pharmacological Evaluation of Novel Potential Ultrashortacting β-Blockers. -Eight new derivatives of β-adrenergic receptor blocking phenoxyaminopropanols such as (VIII) are prepared by a four-step synthesis. Incorporation of an ester group between the aromatic and amine moiety of the connecting chain leads to a decrease of the β-adrenergic receptor blocking activity of the original compounds. All the compounds show moderate antiisoprenaline activity and antiarrhythmic activity. The cardioselectivity is low for methyl-and ethylcarbonyl derivatives but increases significantly for propyl-and butylcarbonyl derivatives. -(MOKRY, P.; ZEMANOVA, M.; CSOELLEI*, J.; RACANSKA, E.; TUMOVA, I.; Pharmazie 58 (2003) 1, 18-21; Inst. Chem. Drugs, Fac. Pharm., Univ. Vet. Pharm. Sci., Brno, Czech Republic; Eng.) -H. Hoennerscheid 21-090
3-and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl]piperazinium Chlorides. -A variety of title piperazine derivatives (IV) (11 examples) are synthesized and evaluated for their antiarrhythmic activity. Except for derivative (IVc), the most potent compound, all the compounds synthesized possess only moderate antiarrhythmic activity. -(MALIK, I.; SEDLAROVA, E.; CSOELLEI, J.; RACANSKA, E.; CIZMARIK, J.; KURFUERST, P.; Sci. Pharm. 72 (2004) 4, 283-291; Dep. Pharm. Chem., Fac. Pharm., Comenius Univ., SK-832 32 Bratislava, Slovakia; Eng.) -C. Hettrich
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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