uprostenol. In the rat uterus, PGF 2a 1-OH was about two orders of magnitude less potent than 17-phenyl PGF 2a whereas PGF 2a 1-OCH 3 produced only a minimal e ect. 4 Radioligand binding studies on cat lung parenchymal plasma membrane preparations suggested that the cat lung parenchyma does not contain a homogeneous population of receptors that equally respond to PGF 2a 1-OH, PGF 2a 1-OCH 3 , and classical FP receptor agonists. 5 Studies on smooth muscle preparations and cells containing DP, EP 1 , EP 2 , EP 3 , EP 4 , IP, and TP receptors indicated that the activity of PGF 2a 1-OH and PGF 2a 1-OCH 3 could not be ascribed to interaction with these receptors. 6 The potent e ects of PGF 2a 1-OH and PGF 2a 1-OCH 3 on the cat lung parenchyma are di cult to describe in terms of interaction with the FP or any other known prostanoid receptor.
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