A commercial strain of the fungus Pleurotus ostreatus was used to mediate the degradation of lindane, by landfarming technology during a 4 weeks statistical experiment. The Multilevel Factorial Design was used with two design factors, namely, straw content X 1 (%) and lindane content X 2 (ppm). The optimization parameters (responses) investigated were: biodegradation rate Y 1 (μg d −1 ), biomass growth rate Y 2 (mg d −1 ), biodegradation/biomass Y 3 (μg mg −1 ), total organic carbon Y 4 (%), total organic nitrogen Y 5 (%) and total organic carbon/total organic nitrogen Y 6 . The optima of the adequate models obtained for the period of 2 and 4-weeks were found. An overall kinetic study, conducted in this work with the aid of experimental design, determined the optimum (maximum) specific lindane degradation rate to be 0.16 g kg −1 month −1 .
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