Pyridine derivatives R 0380Synthesis of 6-Bromomethyl-Substituted Derivatives of Pyridin-2(1H)-ones and Their Reaction with Nucleophiles. -Radical bromination of pyridinone (IIIa) in CHCl3 proceeds with subsequent lactonization [→(V)] of the intermediate bromomethyl derivative (IV), while bromination of (III) in AcOH leads to the oxidized form of bromomethyl derivative (IV), i.e. compounds (VI). Compound (VIa) is used for the preparation of several new aminomethyl-substituted pyridinones, thieno-and furopyridinones. -(KALME, Z. A.; ZHALUBOVSKIS, R. A.; SHMIDLERS, A.; CELMINS, J.; DUBURS, G.; Chem. Heterocycl.
Pyridine derivatives R 0380Unexpected Reaction on Bromination of 3,4-Dihydropyridin-2(1H)-ones with N-Bromosuccinimide. -Bromination of dihydropyridinone (III) affords the lipophilic tetrahydropyridones (IV) instead of the expected bromomethyldihydropyridones (V). -(KALME*, Z.; SMIDLERS, A.; CELMINS, J.; LIEPINSH, E.; KRAUZE, A.; DUBURS, G.; Chem. Heterocycl.
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