Secondary diabetes following pancreatectomy in the dog was prevented by autotransplantation of pancreatic fragments in the spleen. The function and composition of the endocrine elements were analyzed by functional studies and by light and electron microscopy at 4, 8, and 24 weeks. During these different periods, splenectomy proved that all the animals were dependent on the transplanted tissue for normoglycemia. The morphologic study of the spleen showed the survival of the intrinsic pancreatic ganglia as well as the presence of an amyelinic, terminal nervous network, with adrenergic varicosities, exclusively related to the endocrine dements.Nerve endings were identified in close contact with beta, alpha-2, and alpha-1 cells, either isolated in the splenic pulp or forming insular structures with a variable size and composition. No cholinergic varicosities could be identified nor was there any innervation in the ductal and acinar tissue.From 4 weeks on, Schwann cells could be seen coating large surfaces of the endocrine cells at the same time as they sheathed nervous elements, thus creating true "neuroinsular complexes" with beta and alpha-2 cells. The few ganglia that could only be identified under light microscopy, as well as the ultrastructural characteristics of the innervation, suggest that the sympathetic fibers of the perivascular, trabecular and capsular plexus of the spleen had grown and invaded the inoculated endocrine tissue in the splenic pulp.

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Background: Pesticide poisoning is an important cause of morbidity and mortality in many countries in the world. The present study was conducted to assess gross mucosal stomach finding in fatal poisoning. Materials & methods:The present study was conducted on 54 deaths due to poisons of both genders. Stomach was dissected. Gross examination stomach was done and findings such as mucosa appearance-findings like pale, congestion, hemorrhage, erosion, flatten rugae, edema, colour changes were noted. Results: Out of 54 patients, males were 30 and females were 24. Common poison used was Organophosphorous in 32, Sulphuric acid in 10, Hydrochloric acid in 6, Carbon monoxide in 2 and Organochlorines in 4 cases. The difference was significant (P<0.05). Gross mucosal findings was paleness I 32, hemorrhage in 11, congestion in 16, erosion in 32, edema in 45 and flatten rugae in 39 cases. The difference was significant (P<0.05). Conclusion: Authors found that most common poisoning was organophosphorous followed by sulphuric acid.