Situs inversus totalis (SIT) entails a mirror-image reversal of all the asymmetrical structures of the body. Many people with situs inversus are unaware of the condition. Kartagener′s syndrome (KS) is a subset of a larger group of ciliary motility disorders called primary ciliary dyskinesias, comprising a triad of situs inversus, bronchiectasis and sinusitis. We found 6 cases of Situs inversus totalis (SIT) over one year period among admitted patients in our department at ESIC MC PGIMSR and on evaluation 2patients were found to have Kartagener′s syndrome (KS). As the syndrome is rare we hereby report the manifestations and findings in detail.
Alcohol induced cirrhosis prevalence has increased worldwide of late and has added markedly to the global burden of diseases. However, research involving quality of life as treatment outcome for alcoholic liver disease is limited. The primary objective of the study was to evaluate the health related quality of life and factors affecting it in alcoholic liver disease patients. Secondary objective was to analyze mental health status and prescription pattern in alcoholic liver disease patients. Patients, eligible to participate, were briefed regarding the purpose of the study and informed consent was obtained. Self-designed case report form and validated questionnaires were used to record information on physical, mental and emotional functioning of the patient. The study included 51 patients. It was found that majority had low quality of life scores with role limitation due to physical health (5.39 ± 16.9) domain being the most affected. It was also found that the symptom fatigue caused the most hindrance to patient’s daily activities (1.31± 1.20). Most of the patients reported having mild depression (50.98%). Prescription analysis showed that diuretics (74.50%) and drugs for hepatic encephalopathy were the most commonly used drugs. The present study found that alcoholic liver disease considerably impaired health related quality of life and identified the contributing factors as presence of complication, age, severity of disease and symptoms like fatigue and abdominal pain. Hence, evaluating factors affecting quality of life and prescription patterns help identify targets for novel treatment strategies.
BACKGROUNDDengue viral infections are among the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public health concern. Spread of disease has led to increased recognition of atypical manifestations apart from the classical clinical features of dengue infection.
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