Many neurons in the caudal nucleus tractus solitarii (NTS) recorded in vivo respond to moderate glycemic fluctuations through the local action of glucose molecules. To investigate this sensitivity in vitro, the extracellular activity of 112 neurons was recorded in hindbrain slices: 57 changed in firing rate when the glucose level in the bathing medium was increased by 2 mM. Since the glucose-responding neurons were located in catecholaminergic regions and depressed by the alpha-2 adrenoceptor agonist clonidine, they were likely to be adrenergic or noradrenergic. A comparison of the responses to glucose and 2-deoxy-D-glucose suggested that the bioenergetic metabolism is involved in NTS sensitivity to glucose.

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