Periodinane2 2 is a mild, selective reagent for the oxidation of primary and secondary alcohols to aldehydes and ketones.Sir: We report a readily prepared and relatively inexpensive 12-I-51 organoiodine compound, periodinane 2, which is useful for the facile and efficient oxidation of primary alcohols to aldehydes and secondary alcohols to ketones. The reaction avoids some of the difficulties encountered in using other methods3 for the oxidation of alcohols such as long reaction times,3c difficult workup procedures,3d or the need to use a large excess of the oxidizing agent.3cTreatment of 2-iodobenzoic acid with KBr03 in H2S04 gives the cyclic tautomer of 2-iodoxybenzoic acid, 1, in 93% yield.4 A stirred slurry of 1 (25.0 g, 0.089 mol) in acetic anhydride (84.0 g, 0.83 mol) and acetic acid (70 mL) was heated to 100 °C. After 40 min the solid had dissolved.The solvent was removed under vacuum at room temperature until a thick slurry remained. Filtering the slurry in an inert atmosphere and washing with 180 mL of ether gave 25'6 (35.1 g, 0.083 mol, 93%) in 87% overall yield from the iodobenzoic acid. Periodinane 2 has an indefinite shelf life in a sealed container. Long-term exposure to atmospheric moisture results in hydrolysis, but it can be used(1) The N-X-L designation, for a compound in which N valence shell electrons are formally involved in binding L ligands to the central atom X, was described earlier:

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Approximately 40% of college students reported engaging in heavy episodic or “binge” drinking in the 2 weeks prior to being surveyed. Research indicates that college students suffering from depression are more likely to report experiencing negative consequences related to their drinking than other students are. The reasons for this relationship have not been well-studied. Hence, the purpose of this study was to determine whether use of protective behavioral strategies (PBS), defined as cognitive-behavioral strategies an individual can use when drinking alcohol that limit both consumption and alcohol-related problems, mediated the relationship between depressive symptoms and alcohol-related negative consequences among college students. Data were obtained from 686 participants from a large, public university who were referred to an alcohol intervention as a result of violating on-campus alcohol policies. Results from structural equation modeling analyses indicated that use of PBS partially mediated the relationship between depressive symptoms and alcohol-related negative consequences. Implications for clinicians treating college students who report experiencing depressive symptoms or consuming alcohol are discussed.