The UV./HPLC. detection sensitivity of cyclosporine A 1, an immunosuppressive cyclic undecapeptide containing one D-aminoacid and seven N-methylated aminoacids, is enhanced by a factor of 3-4 (limit of detection 5 ng) by conversion of the characteristic side chain of amino-acid-1 to the P-naphthylseleno-substituted tetrahydrofuran derivative 4.Das an sieben der elf Aminosaurebausteine N-methylierte, cyclische Undecapeptid Cyclosporin A 1 ist wegen seiner immunosuppressiven Wirkung interessant [ 11. Charakteristisch ist die ungewohnliche C,-Aminosaure-I, ') Korrespondenzautoren.
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