(Anesthesiology. 2017;127(1):50–57)
Epidural infusions for labor analgesia have traditionally consisted of a local anesthetic and an adjuvant opioid, but these epidurally administered opioids can produce undesirable side effects, such as pruritus and decreased fetal heart rate variability.
Background-Preclinical data suggest that oxytocin reduces hypersensitivity by actions in the spinal cord, but whether it produces antinociception to acute stimuli is unclear. Here we examined the safety of intrathecal oxytocin and screen its effects on acute noxious stimuli.
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