Polymorphonuclear cell function tests were performed in 340 patients with recurrent unexplained infections. Serum-dependent defects in phagocytosis and intracellular killing of Candida albicans (Candida opsonin and procidin defects) were specifically associated with susceptibility to recurrent pyogenic infections, Candida opsonin defects occurring in 12.7% and Candida procidin defects in 20.8% of patients compared with 3.7% of healthy controls. Saccharomyces cerevisiae opsonin deficiencies were also found frequently in patients with recurrent infections, being present in 18.2% compared with 7.4% controls, although not specifically in those with pyogenic infection.
~v a l~h a s~r e r i o u s~h d e n m s t r a t e d b y~l s t o b e a n e j o r a l l e r g e n o f h e n ' s e g g(Folia Allapl.Imnrml.Qin. 33,B (1953) ~U i c n t g t s v i t h o v a l t u n i n ( 1 1 r g u p t o l g )~p e r f o w d i n a l l p t i e n t s .After oral pmvccatim a typical inndate hp&tivity reBCtim (urticaria, a%thra, i n~s y m p t o n s )~i r d u c e d i n 1 7 a r t o f 2 6~. N e i t h e r t h e~o f Cord-blood I& was determined prospectively in 300 neonates by an enzyme-hmo-assay (Phadezym-Prist ) (EIA) and a radio-immulo-assay (Phadebas-Prist) (RIA). In order to obtain sufficient sensitivity for the EIA, determinations were performed with undiluted sera, and calibration curves were newly established. The lowest value determined was at 0.125 kU/1. A comparison of EIA and RIA revealed no significant differences for single determinations. The geometric mean was 0.246 kU/l; 2-SD was 1.0 kU/1 for both test systems. 10% of the cord-blood values were above 1.0 kU/1 (n=29 neonates); a follow-up of these 29 infants 18 rnonths after birth detected 19 with symptoms of atopy (atopic demtitis=l4; allergic asthm=il; urticaria with cow-milk-allergy=l). The presented data would s-est that EIA and RIA are comparably sensitive and valuable rethods for the determination of I@-levels in cord-blood. A r early risk factor for the development of atopic diseases in infancy can thus be detected. In addition, 200 of the 300 cord-blood sera were studied for T-and Fe02, FeC02, minute ventilation (OE), breathing frequency (BF), heart rate (HR), blood pressure (BP), oxygen consumption (602) and respiratory exchange ratio (QR) were determinated during each stage of the progressive exercise and during the recovery. In the asthmatic group, there are significant decreases of Fe02, FeC02, V02, load and QR at each stage and during the maximal exercise (Table I) The cardiac and respiratory recovery at 10 min were slower in A than C : BF = 120 + 11 vs 104 + 3 (p<0,01) and Dt02 = 0,10 5 O,11Ventilation-perfusion maldistribution and obstruction during the exercisc could explain the little limitation at the exercise in this group of asthmatic children. SCG EFFECT ON MACROMOLECULAR ABSORPTION OF FOOD ANTIGENS IN AToPIc DERMATITIS (AD).
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