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We describe a scheme of molecular tagging velocimetry in air in which nitric oxide (NO) molecules are created out of O2 and N2 molecules in the focus of a strong laser beam. The NO molecules are visualized a while later by laser-induced fluorescence. The precision of the molecular tagging velocimetry of gas flows is affected by the gradual blurring of the written patterns through molecular diffusion. In the case of turbulent flows, molecular diffusion poses a fundamental limit on the resolution of the smallest scales in the flow. We study the diffusion of written patterns in detail for our tagging scheme which, at short (micros) delay times is slightly anomalous due to local heating by absorption of laser radiation. We show that our experiments agree with a simple convection-diffusion model that allows us to estimate the temperature rise upon writing. Molecular tagging can be a highly nonlinear process, which affects the art of writing. We find that our tagging scheme is (only) quadratic in the intensity of the writing laser.

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The pharmacokinetics of ethylene are determined using laser based photoacoustic detection and a closed chamber setup. Concentration-time data are analyzed using a two-compartment and a physiologically based pharmacokinetic (PBPK) model. Endogenous production was 92 ± 13 pmol· h −1 kg −1 for the two-compartment model and 75 ± 10 pmol·h −1 ·kg −1 for the PBPK model. These values agree with previous work at our department, but are significantly lower than published values based on gas chromatography. The blood:air partition coefficient in the PBPK model was determined by curve fitting, because simulations based on published values did not agree well with data. Curve fitting gave a value of 0.092 ± 0.029. The real-time nature and high sensitivity of photoacoustic detection make it a useful addition to gas chromatography in closed chamber studies.