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The electrochemical behaviour of N-hydroxy-3-isopropyl-2,6-difurylpiperidin-4-one semicarbazone and N-hydroxy-3-isopropyl-2,6-difurylpiperidin-4-one thiosemicarbazone have been evaluated using cyclic voltammetric method with variable scan rates. Based on the number of cathodic and anodic peak, peak current and number of stop crossing level it is concluded that an irreversible reduction taken place for both the synthesised compounds. The presence of the electron-donating carbonyl and thionyl group of semicarbazone and thiosemicarbazone leads to a shift of the irreversible reduction potential towards cathodic value. The products have been isolated and their structure is confirmed by 1 H NMR and 13 C NMR spectroscopy. Further the reduced products were screened for antibacterial activity. On comparison the semicarbazone compound showed high inhibition towards Pseudomonas aeruginosa among the eight test bacteria.

A series of 3-ethyl-2,6-diarylpiperidin-4-one thiosemicarbazone and 3,5-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazone were synthesised. The thiosemicarbazones were subjected to cyclic voltammetric study using graphite electrode with variable scan rate at moderate acidic conditions maintained in the electrolytic solution. The reduction takes place by two electron transfer and the reaction is pH dependent. The reduced products were isolated and purified by column chromatography. The structure was proved by 1H and 13C NMR spectroscopy. The electrode process was found to be irreversible and diffusion controlled. Further the products were analysed for anti fungal activity in which nitro substituted compound showed high inhibition towards the fungi Asperillus niger

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