Insolubilized antibody against human transcobalamin I has been used as a specific and precise tool for the separation of transcobalamin I (and III) from transcobalamin II. Range and mean (in parentheses) for the unsaturated binding capacity for twenty samples are 40-190 (90) pmol/l and 220-1170 (560) pmol/l for transcobalamin I (and III) and transcobalamin II, respectively. The similar figures for the cobalamin saturated transcobalamins are 200-549 (320) pmol/l and 75-475 (160 pmol/l. On analyses of the cobalamins attached to each of the transcobalamins, it is shown that methylcobalamin accounts for most of the cobalamins attached to transcobalamin I whereas transcobalamin II carries most of the 5'-deoxyadenosylcobalamin.
Introduction: As a result of national and international guidelines, in recent years treatment of endometrial carcinoma (EC) has become more centralised. In the UK this has led to the development of regional cancer networks, with sub-specialists gynaecological-oncologists leading treatment in regional centres. A tool in appropriate triage of patients to treatment at central or peripheral units is magnetic resonance imaging (MRI). Objective: To assess if MRI is an effective tool in triaging place of treatment within the Cancer Network. Methods: Between March 2006 and December 2007 an audit was undertaken, comparing MRI and histology reports in women with tissue diagnosis of EC. The MRI reports were matched to histology and International Federation of Gynecology and Obstetrics (FIGO) staging was compared. A review of guidance and expected accuracy was also performed. Results: Forty-three cases were analysed. Sensitivity or MRI for overall myometrial invasion was 88%, a positive predictive value (ppv) of 94% and a negative predictive value (npv) of 56%. 65.2% of reports commented on cervical involvement clearly, which was accurate in 44.2% cases. For cervical involvement, sensitivity was 57%, specificity 75%, ppv 44% and npv 83%. Conclusions: Practical reporting in our Network structure falls short of expectations. Standardisation of reporting under named lead
The prevalence of unidentified diabetes was 3.3% based on a single HbA measurement. Furthermore, 16.7% of those reporting not to have diabetes had an HbA level of 41-48 mmol/mol (5.9-6.5%), representing a subgroup with an increased risk of developing diabetes. Among those with self-reported diabetes, 30.1% had an HbA level ≥58 mmol/mol (7.5%) and 6.3% had a level >74 mmol/mol (8.9%).
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