Background: Diabetes alters keratinocyte proliferation and tissue granulation during wound healing, thereby delaying the healing process. Thus, we studied the correlation between keratinocyte proliferation and tissue granulation with healing stages and the impact of camel milk peptide (CMP). Methods: Rats were grouped into wounded normal, wounded diabetic and wounded diabetic with daily treatment of CMP at a dose of 100 mg/kg of body weight. One-way ANOVA and Tukey’s method were used to compare the overall effects of each treatment. Result: Diabetes strikingly impaired Protein kinase B (Akt) and Alpha Smooth Muscle Actin (SMA-á) concentrations in the wounded tissues. Furthermore, the gene expression of KGF in wounded tissues was downregulated in diabetic rats. Conversely, CMP showed notable restoration of these parameters. Thus, granulation was enhanced compared with that in non-treated diabetic rats. In addition, the wound margin epithelia of CMP-diabetic rats showed an increase in both size and migration, with two epidermal tongues directed inward and clearly visible on both sides of the wound. However, diabetic rats showed increased extent of wound margin neoepithelia without clear epidermal tongues. These data confirmed the potential role of CMP in wound healing in diabetic rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.