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A series of novel platinum(II)-2,2':6',2' '-terpyridine (trpy) complexes containing (thioalkyl)dicarba-closo-dodecaborane(12) (closo-carborane) derivatives were prepared by treatment of the labile precursor species [Pt(MeCN)(trpy)](OTf)2 with R(CH2)nSH (R = closo-1,2-carborane, n = 0-3; R = closo-1,7-carborane, n = 1; R = closo-1,12-carborane, n = 1) in the presence of NEt3 to afford brightly colored complexes of the type [PtS(CH2)nR(trpy)]OTf. All products were characterized by means of multinuclear (1H, 13C, 11B, and 195Pt) 1D- and 2D-NMR spectroscopy, ESI-MS, and, for the 1,7-carborane derivative, X-ray crystallography. Preliminary in vitro cytotoxicity studies of selected complexes against human ovarian carcinoma cells are also reported.

The first examples of DNA metallointercalators containing a dicarba-closo-dodecaborane(12) (carborane) moiety are presented. Treatment of the labile platinum(II) complex [Pt(OTf)(terpy)](+) (terpy = 2,2':6',2' '-terpyridine) with the 1,2-carborane monothiol derivatives 1-HS(CH(2))(n)-1,2-C(2)B(10)H(11) (n = 0, 1) or the novel 1,7-carborane ligand, 1-HSCH(2)-1,7-C(2)B(10)H(11), affords the stable, brightly colored species [Pt(1-S(CH(2))(n)-1,Z-C(2)B(10)H(11))(terpy)](+) (Z = 2, n = 0, 1; Z = 7, n = 1) in good yield and purity. Preliminary DNA-binding experiments with calf-thymus DNA indicate an intercalative interaction by the platinum(II) complexes at high r(f) values.

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