mixture of 25,uc of [3H]uridine and 25 ,c of [3H]guanosine. RNA was extracted separately from the uteri of the control and test groups.In other experiments, by the dual-labelling procedure of Ellem (1967), the test animals received 1 ,ug. of oestradiol 90min. before being killed and the controls were given O-lml. of 0-9% (w/v) NaCl. At the same time, the controls were given 100,uc of [3H]uridine and the test animals received 25,uc of [14C]uridine. The uteri from both groups were pooled before extraction of the RNA.No significant differences were observed in the distribution of ultraviolet-absorbing material from the test and control animals. However, in the experiments with 3H-labelled precursors the total radioactivity recovered from the MAK columns of RNA from treated animals was 72% greater than from the controls. The greatest change occurred in the QI RNA peak which showed an increase of 150% over the controls, whereas the ribosomal RNA peak increased by 67%. Smaller increases
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