To identify receptor-associated proteins that may contribute to the specificity of insulin and IGF-I signaling responses, a mouse embryo library was screened using the yeast two-hybrid system. Multiple receptor-interactive clones encoding the SH2 domain of the adapter protein Grb10 were isolated. Subsequent cloning of the full-length Grb10 sequence from a mouse fat cDNA library defined a previously unknown Grb10
The mean distance reflecting the magnitude of AP (x) and ML (y) sway was analyzed by repeated measures ANOVA. Comparing with healthy control, patients with SAOA showed a larger mean distance. In Root Mean Square of Velocity (RMS) analysis, there was also a significant difference between 3 groups. As a result of Post-Hoc test, there was a significant difference between SAOA and PD group, and between SAOA and control group, however, there was no difference between PD and control group. In RMS acceleration analysis, three groups showed statistically significant differences. In detail, there were significant differences between SAOA and PD group, SAOA and control groups, but not between PD and control group. Conclusions RMS and RMS acceleration showed disease specific characteristics. Our study shows not only usefulness as assessment tool but also evidence that has disease specific postural control system in neurodegenerative disease.
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