This has been evolved with a modified pulse duplicator and the use of a hot film probe for measuring velocity, direction, and turbulence. Many of the commercially available mitral valve prostheses are being investigated for their flow characteristics. In addition, efficiency is being examined and some unusual findings point to the possibility of a hydraulic ram effect in the normal mitral valve that allows opening to commence before the end of ventricular systole.TRIAL OF A NEW ANTI-MYXOVIRUS COMPOUND J. E. STARK Two hundred and sixty-four male students living in a hall of residence volunteered to take part in the trial and were randomly allocated into two groups. One group received a synthetic isoquinoline derivative (UK. 2371) daily in divided doses and the other group received identical placebo tablets.During the five weeks of the trial tablets were distributed daily and volunteers were asked to return any tablets which had not been taken. As an additional guide to tablet acceptance a small quantity of isoniazid was incorporated into some active and placebo tablets and urine samples collected at appropriate times were tested for isoniazid derivatives.Volunteers were questioned each week about their health and were asked to report all respiratory and other illnesses. All respiratory illnesses were fully investigated for virus and mycoplasma infections. Full toxicity studies were carried out.The preliminary findings are reported with particular reference to (1) protection against acute respiratory illness provided by the drug; (2) assessment of the novel isoniazid marker system; and (3) the factors affecting acceptance of medication by volunteers.MYCOPLASMA PNEUMONIAE M. C. JONES A retrospective study was made of 100 cases of infection with Mycoplav.n nneumoniae notified through the Public Health Laboratory four-weekly review during 1967-68, and diagnosed by isolation or complement fixation studies. The mode of presentation, physical, radiological and haematological findings, complications, treatment, and progress are reported.The results are also presented of an investigation into the isolation rate of Mycoplasma species (including pneumoniae, hominis, orale, and salivarium) from the nasopharynx of patients admitted to hospital with acute exacerbations of asthma, bronchitis or bronchiectasis and from the nasopharynx and bronchial tree of patients submitted to bronchoscopy. We measured the heat debt incurred during thoracotomy, first with no particular measures taken to prevent heat loss and, secondly, using a heat-reflecting aluminium foil blanket wrapped around the lower half of the patient.Our method of measuring heat loss was adapted from that of Burton and Benzinger. Deep body, calf, forearm, and abdominal skin temperatures were measured. From these readings the average body temperature and the change in heat content were calculated.Our results are of interest for several reasons: 1. The average heat debt without precautions against heat loss was 20 Kals per hour. This involves a doubling of the metabolic ...
We report a prospective trial to establish whether a subcutaneous fat stitch reduces the incidence of haematoma formation, infection and wound dehiscence following saphenous vein excision for coronary revascularization. Two groups of patients undergoing coronary revascularization were studied. In the first group of 100 patients the saphenous vein was harvested from both legs. Legs were randomized to have either a fat stitch or no fat stitch during wound closure. By using both legs of each patient we eliminated the effect of general factors on wound healing, thus the patients acted as their own controls. In the second group of 200 patients, the saphenous vein was harvested from the thigh, and patients randomly allocated to either a fat stitch or no fat stitch during wound closure. The wounds were examined daily for 7 days, and again after 6 weeks at the follow-up. There was no difference in the rate of wound complication in the fat stitch groups (9%) compared with the no fat stitch groups (8%), however, the fat stitch groups required more surgical intervention for skin edge necrosis. It appears that closure of the subcutaneous fat following saphenectomy is unnecessary, and may be detrimental to skin healing.
Sixty patients undergoing coronary artery bypass surgery were studied prospectively in order to investigate the effect of a cardioselective beta-blocker on the incidence of postoperative supraventricular arrhythmias. Patients with good left ventricular function were randomly divided into two groups: 30 patients treated with atenolol and 30 patients acting as controls. Atrial fibrillation was seen in 11 patients and frequent premature atrial extrasystoles were noted in one. Eleven (37%) patients in the control group experienced arrhythmias whilst atenolol significantly reduced this incidence to 3% (one patient), P = 0.001. There was no significant relationship between the development of supraventricular arrhythmias and the following variables: age, sex, severity of preoperative symptoms, previous myocardial infarction, extent of coronary artery disease, technique of myocardial preservation used, ischaemic time, number and site of saphenous vein grafts, endarterectomies performed and perioperative serum potassium levels. It is concluded that the use of atenolol (started 72 h before operation) is effective in reducing the incidence of supraventricular arrhythmias following elective coronary artery bypass operations in patients with good left ventricular function.
Our aim in this report is, first, to explain why we think it is important to measure body temperatures during operation and, secondly, to describe a simple way to lessen heat loss during thoracotomy.We became interested in the subject of heat loss after reading the work of Benzinger (1967), Roe, Goldberg, Blair, and Kinney (1966) and Cuthbertson, Smith, and Tillstone (1968). Benzinger (1967) from Bethesda has established a quantitative relationship between a fall in body temperature and a rise in metabolic rate. He has summarized some of his findings in a graph which is reproduced in Figure 1
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.