Discussion.-PROF. I. M. Rorrr (Middlesex Hospital) suggested that any lymphocyte might become a "killer" if exposed to a non-specific stimulus such as an antigenantibody complex or aggrated gamma-globulin plus complement. DR. MACLENNAN agreed that this was a possible explanation. He produced experimental evidence which suggested that complement components were unlikely to play a significant part in his particular experiments. DR. M. K. JASANI (Horsham) asked if the increased cytotoxicity could be due to stimulation of lymphocytes by an antigen present in synovial fluid. DR. MACLENNAN thought that, in his series of experiments, this possibility could be excluded.
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