Chronic non-infectious diseases are characterized by irregular morbidity and mortality throughout a year. Aim. To study excess cardiovascular morbidity during winter in Ivanovo Region in 2009-2013 years. Material and methods. Excess winter morbidity index (EWMI) was calculated using special formula. The incidence of cardiovascular diseases (CVDs) was determined according to the data from the medical information-analytic center of Ivanovo Region. The index was calculated for CVDs in general, for arterial hypertension (HT) and for acute forms of CVDs (acute myocardial infarction and stroke). Results. The mean EWMI for CVDs for 5 years of the follow-up made up to 77.2% and was higher in women than in men (80% vs 69.5%, respectively). People of working age had lower excess winter morbidity than the population older than working age (53.1% and 88%, respectively). EWMI for CVDs had significant variability and ranged from 29.0% (2013 year) to 81.1% (2010 year) in men and from 25.2% to 82.9% in women in the same years. In general, the 5-year mean EWMI for HT was 72.7%; it was higher in men than in women in most of the analyzed years of follow-up. We had revealed the heterogeneity of the EWMI for HT during the analyzed period in each analyzed group (the minimal values were found in 2011 after the heat wave in 2010). EWMI for myocardial infarction demonstrated excess winter morbidity, men and women had in general similar indices (31.0% and 28.4%, respectively), but it was higher in people of working age as compared with the older ones. This index had a wide range of values. In case of stroke we had revealed no excess winter morbidity; this index was equal throughout a year. Conclusion. The influence on excess winter morbidity can result in the reduction of cardiovascular morbidity and mortality due to the decreased effect of risk factors; it would also optimize a load on healthcare system, the season irregularity of which must be taken into account when planning a work of medical centers. Материал и методы. Проведен расчет индекса избыточной заболеваемости в зимний период (ИИЗЗП) по специальной формуле. Количество ССЗ определяли по данным медицин-ского информационно-аналитического центра Ивановской области. Индекс рассчитывали для ССЗ в целом, для артериальной гипертензии (АГ) и для острых форм ССЗ (инфаркт мио-карда и инсульт). Результаты. Средний ИИЗЗП для ССЗ за 5 лет составил 77,2%, и оказался у женщин несколько выше, чем у мужчин (80,0% против 69,5%, соответственно). Среди лиц трудоспособ-ного возраста избыточная заболеваемость в зимний период оказалась ниже, чем среди населения старше трудоспособного возраста (53,1 и 88%, соответственно). ИИЗЗП для ССЗ характеризовался значительной вариабельностью и колебался от 29,0% (2013 г.) до 81,1% (2010 г.) у мужчин и от 25,2% до 82,9% у женщин в те же годы. Средний за 5 лет ИИЗЗП для АГ в целом составил 72,7%, выше -у мужчин в сравнении с женщинами в большинстве анализируемых лет наблюдения. Выявлена неоднородность показателя ИИЗЗП для АГ в течение анализируемого периода в ка...
An epidemics of obesity in the world during recent two decades, has already led to increased prevalence of diabetes, metabolic syndrome, oncological diseases, etc. Obesity is assessed with a variety of indexes, and recently the number of such tools was added with the two additional: visceral obesity index (VOI) and index of lipid products deposition (ILPD). The aim of the study — evaluation of the relation of anthropometric parameters with coronary heart disease. Materials of the study were representative selections from 13 regions of the ESSE-RF trial. In analysis of associations of body mass index (BMI), waist circumference (WC), relation of WC to height (WC/height x 100), VOI and IPLD with correction on the age and region, it was found that all studied parameters are significantly correlated with ischemic heart disease, however when the main risk factors were added, only two remained — odds ratio (95% confidence interval) for: WC/height×100 — 1,030 (1,019;1,040) (р<0,0001) and VOI — 1,053 (1,020;1,087) (р<0,0015) in males and WC/height×100 — 1,027 (1,021;1,033) (р<0,0001) and VOI — 1,052 (1,022;1,083) (р<0,0007) in females. It is important to note almost identical values of odds ratio for the indexes in both sexes. Reliability of the models obtained is confirmed by ROC analysis, where the area under curve for males was 0,68 and for females 0,67. The results witness on legitimacy of search for novel parameters of obesity that would have good reproducibility and are also simple and easy to use.
USD, representing the 0.02536% of the budget of the NHS. The deterministic sensitivity analysis confirm that the results were robust. ConCluSionS: According to the results of the BIA, the inclusion of bosentan to the NHS of Mexico is displayed as an affordable option for the treatment of pediatric patients (2-12 years) with HAP.
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