Administration of thrice-weekly liposomal amphotericin in a hospital-associated, outpatient infusion centre may be a promising option for stepdown treatment in patients unable to take itraconazole.
Background The hypersensitivity reactions after docetaxel administration is a main concern in this study. The aim of this study is to check the incidence of hypersensitivity reactions (HSRs) after receiving a single dose of intravenous dexamethasone before docetaxel administration Method In this retrospective study, 1 year data from Jan 1st 2018 to Dec 31st 2018 was retrieved from hospital information system (HIS). We examined 210 patients who visited hospital during the last 12 months during their cancer treatment and took dexamethasone orally 3 days prior to docetaxel administration or 20 mg intravenously before 15 minutes of docetaxel. Results Out of 210 patients, only 50 patients were taking IV dexamethasone injection prior to docetaxel constitutes only 23.5% while patients who were taking oral dexamethasone were found to be 160 which constitutes 75%. There was no hypersensitivity reaction with oral and IV dexamethasone before docetaxel administration. Majority of the patients were without taking oral dexamethasone before docetaxel administration which not only saved time but also improve patient compliance. Conclusion No hypersensitivity reaction had been found either in oral or intravenous dexamethasone prior to docetaxel administration by using patient data from Hospital Information System (HIS). However, intravenous dexamethasone not only improve patient compliance but also reduce the risk of hypersensitivity reactions but the cost of intravenous dexamethasone is higher than the cost of oral dexamethasone. In conclusion, single dose of intravenous IV dexamethasone is preferred treatment option.
Asthma means chronic (long term) illness of the lungs causing cough, shortness of breath, chest tightness, wheezing and fast respirations, which is influenced by several genetic developments and environmental factors that affect over 300 million people around the world and 1 in 4 urban children. The occurrence of asthma increased in the world over the last 25 years. Environmental factors such as air pollution allergens, infection, smoking, hormones, and some specific medicine take part in this disorder. Currently there are different therapies to overcome this disease like Herbal, Unani, Ayurveda, Siddha, Homeopathy, Naturopathy, Allopathy, Biochemical and Chinese herbs. Allopathic treatment is also available for majority of the disorders but the problem is increasing price of medication now a days and allopathic medicines are related with a diversity of side effects. So tendency towards management of asthma with modern therapies like intake of nutritional diet and modification in our lifestyle including exercise, yoga are highly adopted these days.
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