Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a double proteinopathy: deposition of amyloid-β into plaques and hyperphosphorylation of Tau protein. Objectives: To understand the genetic and molecular aspects of Tau protein and its relationship with Alzheimer’s disease. Methods: We conducted a systematic literature search using Pubmed/ MEDLINE and ClinicalKey databases, applying the descriptors: “Alzheimer Disease” AND “Tau proteins’’ AND Tauopathies, during July and August of 2020. The inclusion criteria were English and Portuguese articles published between 2015 and 2020, with human limited study and free full text, excluding images, books, clinical tests, and narrative reviews. After analyzing titles and abstracts, we selected 12 articles and included 7 additional studies. Results: Mapt, the encoder gene of Tau, is located in the 17q21.3 locus and presents 16 exons that, when transcripted, originates 12 copies of mRNA by alternative splicing and 6 Tau’s isoforms. Tau is a microtubule-associated protein (MAP) responsible for cellular cytoskeleton stabilization and maintenance, promoting neuronal axonal transport. A kinase-phosphatase imbalance turns Tau hyperphosphorylated, disassociating it from tubulin and grouping it into insoluble paired helical filaments, which originates neurofibrillary tangles. The tauopathy’s progress causes neurotransmitter destabilization and neuronal death, inducing AD symptomatic manifestations. Conclusions: Due to the gradual worsening of the disease to more debilitating stages, studies focused on deepening the knowledge of genetic and molecular aspects of Tau protein are viable and promising alternatives to improve the quality of patient’s lives.
O novo coronavírus, SARS-CoV-2, muito além de acometer as vias aéreas, também pode promover uma Coagulopatia Intravascular Disseminada. Diante disso, o objetivo do estudo foi entender fisiopatologicamente a Coagulopatia Intravascular Disseminada como uma potencial consequência da COVID-19. Para tanto, foi realizada uma revisão integrativa da literatura utilizando a base de dados MedLine, com a seguinte combinação de descritores: "Infecção por Coronavírus" AND "Coagulação Intravascular Disseminada". Com a leitura e síntese de artigos, foi possível esclarecer que o coronavírus, ao adentrar nas células do organismo humano, provoca a lesão do endotélio vascular, o qual libera citocinas inflamatórias e pode também culminar em ativação plaquetária e, consequentemente, um estado de hipercoagulabilidade. Todo esse processo pode gerar um evento trombótico, que, em estado generalizado e em nível sistêmico de coagulação, é a CID. Logo, a relação entre COVID-19 e CID é passível de ocorrer e está muito presente em pacientes terminais da doença.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.