Objectives The study was aimed at assessing the effects of Lactobacillus rhamnosus yoba on the serum lipid profile and body weight of male Wistar rats fed a high fat diet. Methods 20 seven week old male rats weighing between 120 g and 180 g were used for the study and divided into 4 groups of 5 rats each. The control group was fed normal mice pellets and distilled water, while the other groups were fed mice pellets supplemented with 3% cholesterol and 2% saturated fat in addition to any of distilled water, Lactobacillus rhamnosus yoba or Norvastatin respectively. The body weight was measured at the start of the study and after 2 weeks while serum parameters were measured after 8 weeks. Data was analyzed using SPSS Version 20. ANOVA and Tukey's tests determined significant differences in means at 95% confidence interval. Results Lactobacillus rhamnosus yoba significantly (P < 0.005) modulated weight gain, serum total cholesterol and triglycerides when compared to the control. Similarly, LDL-cholesterol was significantly modulated (P < 0.005) while HDL-cholesterol was significantly enhanced (P < 0.005) when compared to the control. Conclusions The ability of Lactobacillus rhamnosus yoba to elevate HDL cholesterol and modulate LDL-cholesterol without the side effects of statins makes it a potential functional food. In line with the findings, the present study justifies the use of Lactobacillus rhamnosus yoba as a probiotic in fermented foods. Funding Sources NA.
Newbouldia laevis is a valuable tropical plant belonging to the family of Bigoniaceae. The plant is believed by most herbal practitioners to be the tree of fertility and of immense medicinal benefits to humans. This study examined ameliorative potencies of Newbouldia laevis on monosodium glutamate induced toxicity in female albino rats for 14 days. Group A received 800 mg/kg body weight of Monosodium Glutamate (MSG), while Group B received 8,000 mg of MSG + 400 mg of extract. Group C received 8,000 mg of MSG and 600 mg of N. laevis. Group D received feed and water. Group E received 200 mg of extract and Group F received 8,000 mg of MSG. Results showed no significant difference (p > 0.05) in Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) and Total Protein (TP) of rats exposed to MSG + extracts and MSG-alone. Significant (p < 0.05) elevation in Alanine Transferase (ALT) and serum albumin were recorded for rats exposed to MSG + 400 mg and 200 mg of extract. There was no significant difference in cholesterol level in rats exposed to MSG alone compared to other groups. Significant elevation in urea level occurred in rats exposed to 8,000 mg MSG + 600 mg of the extract, reduction occurred in those exposed to 8,000 mg MSG + 400 mg of the extract. Those exposed to normal saline and 200 mg of extract leveled up with rats exposed to MSG. Study indicates protection of liver architecture and ameliorating effect of N. laevis on MSG intoxication.
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