Urinary chondroitin sulfates were measured quantitatively and qualitatively in healthy human males ranging from prematurity to 80 years of age. Between 20 and 30 years of age, chondroitin 4-sulfate the predominant urinary component in the young is displaced by chondroitin 6-sulfate. Chondroitin (molecular weight about 20,000) constitutes 21% of the total glycosaminoglycans in premature infants but rapidly decreased to 2.5 % by 4 years of age.
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