The aim of this thesis is to analyse and to present heterogeneous concepts during projection of facilities of good manufacturing practice and human biobank.Feasibility study for bio banks of stem cells is prepared for one current health institution in Republic of Macedonia. The space covers 105 square meters for biobank for stem cells, as well as additional space. With this projects program are defined requested needs of the investor during preparation of the basic project for the biobank for stem cells. The prepared architectural – constructive solution allow smooth flow of the technology defined by the investor. The solution is optimal related to the function, construction and economics. It was established that in the Republic of Macedonia there is not present any kind of bank for stem cells, but there are present several liaison offices for collection and deposition of stem cells from several foreign countries. It is necessary to project, construct and to put in function several banks for stem cells in the Republic of Macedonia in order to fulfil the needs of patients with malignant diseases
BACKGROUND: The paper analyzes the properties of medium density fiberboards (MDF) intended for furniture production and interior application. Because MDF panels are one of the mostly used wood-based panels in furniture production sector in the Republic of Macedonia it is important to know and understand their basic physical and mechanical properties. AIM: For better understanding of MDF panels and their proper end use by the furniture constructors and designers, physical and mechanical properties of MDF panels present in the market are tested.MATERIALS AND METHODS: Commercially produced MDF panels taken from one company from wood-based panel market were tested. Evaluation of the quality of the panels was made on the basis of the obtained results for the physical and mechanical properties of the panels. Properties of MDF were tested according to the national MKS standards and European norms.RESULTS: Tested MDF panels present on our market are characterized by good physical and mechanical properties that meet the requirements of the standards for MDF for use in dry conditions including furniture production and interior applications.CONCLUSIONS: It is recommended to avoid application of these MDF panels in high humidity conditions for a longer exploitation period. For this kind of applications, such as bathroom areas, the furniture constructors and interior designers should consider use of MDF.H type of panel for application in high humidity conditions, which will provide good dimensional stability of the products during whole exploitation period
BACKGROUND: Bone marrow transplantation is a well-established lifesaving treatment procedure for many patients with various diseases, such as blood cell cancers (leukemia), some severe hematological diseases (aplastic anemia) and some rare diseases, as well as immune deficiency disorders. Allogeneic hematopoietic stem cell transplantation (HSCT) represents a potentially curative therapy for various hematologic disorders and even the only curative treatment for some diseases (e.g., myelodysplastic syndromes). As an alternative donor strategy, in patients lacking a human leukocyte antigen-matched donor or haploidentical donor, mismatched unrelated donors offer the option of using HSCT in this group of patients. Since the establishment of the first registry in the world for recruitment of unrelated bone marrow donors, the number of newly formed registries has increased over the years. In our country, in addition to the government-funded registry, housed at the Institute of Immunobiology and Human Genetics, Faculty of Medicine in Skopje, an additional non-governmental registry was established, Scientific Foundation SPIROSKI - Marrow Donor Registry (MK-SFSMDR). This will contribute to the increase of the number of newly registered donors in the Republic of North Macedonia and will be a great benefit for the patients searching for a bone marrow transplantation. AIM: We aimed to present the establishment of the first MDR in the non-governmental sector of the Republic of North Macedonia and the recruitment strategies of new donors. METHODS: The core activity was the creation, realization, and implementation of the Marrow Donors Recruitment Program. The constructed program for increasing the awareness of the population about HSCT and the importance of becoming a marrow donor encompasses the following activities: (1) creation of a web portal for bone MDR in English, Macedonian, and Albanian language; (2) application of standards from the World Marrow Donor Association for educational material preparation and informed consent creation; (3) composing printed and electronic materials for recruitment activities; (4) organization of public debates for marrow donation in governmental and non-governmental sectors; (5) inclusion of students and other non-governmental organizations for recruitment and registration of marrow donors; and (6) submission the obtained results from Macedonian donors and the donors from other communities (Albanians, Roma, Serbs, Turks, Vlachs, and others) in the database for marrow donors. RESULTS: In 2022, 988 submissions from marrow donors were registered, from which 678 (68.62%) were females and 310 (31.37%) were males. The biggest number of submissions for marrow donors are in the age group of 26–40 years (567 or 57.38%), followed by the age group of 18–25 (270 or 27.32%) and the age group of 41–55 (151 or 15.28%). The most efficient method for new submissions was through social networks, 538 or 54.45% out of 988 registered donors. The second was through word of mouth (200 or 20.24%), the third was onsite marrow donor recruitment actions (145 or 14.68%), followed by information from the websites (19 or 1.92%), and other (86 or 8.70%). From the total Macedonian population (2,062,044), we were able to recruit 988 marrow donors, which is 0.048% of the population. The biggest recruitment percentage was in the Skopje region (0.067%), followed by the Pelagonia region (0.059%) and the Southwest region (0.043%). The lowest participation was in the Polog region (0.011%). The biggest percentage of recruited marrow donors (988) were Macedonians (94.13%), and the rest of them were from the minorities: Albanians (1.92), Turks (0.71%), Roma (0.1%), Croats (0.2%), Bosniaks (0.51%), Vlachs (0.81%), Serbs (1.21%), Macedonian Muslims (0%), and others (0.4%). CONCLUSION: With the establishment of the SFS-MDR (MK-SFSMDR), one of the goals of SFS was achieved, which, together with the publication of scientific journals, enables and contributes to the scientific research in the field of the main tissue-compatible complex and transplantation of cells, tissues, and organs. The results will be used by patients who need bone marrow treatment in our country, in neighboring countries, and around the world.
AIM:The aim of this study was to analyse current scientific impact of published papers about architecture from South East Europe in the Scopus database . MATERIAL AND METHODS:Document search of the Scopus database was performed on October 13, 2015 about architecture in the Scopus Database (1962Database ( -2015. A total number of 572,489 documents worldwide were identified with "architecture" in the title, abstract or keywords. By limitation to South East European countries
INTRODUCTION: The old rural architecture in Macedonia is insufficiently studied and in many villages is in the process of extinction, especially in Western Macedonia where there are many villages whose inhabitants have emigrated. OBJECTIVES: The objective of this research is the folk architecture of the house in the village of Leshok, near Tetovo, and getting acquainted with the other types of objects that are part of the rural-economic yard and are inextricably linked to the daily work, life and customs of the peasant from this region. MATERIAL AND METHODS: For analysis of the traditional architecture of the houses in the village of Leshok from the late 19th and early 20th centuries, 10 typical houses with different structure and location are chosen, which are identified and displayed by the Google Earth search engine. RESULTS: The basic characteristics of the architecture of the village house in Leshok are explained, where the economic yard together with the economic objects are included. The functional solutions of the foundations of houses from the end of the 19th and the beginning of the 20th century are shown, the constructions used in the house of Leshok are described, as well as the materials that were used for their construction. In the end we get acquainted with the interior and the design of the premises in the old Macedonian house. CONCLUSION: Leshok belongs to the group of mountain villages of compact type. The configuration of the terrain, the dead riverbed, dictated the way of construction, where the houses are placed one above the other and each has a clear view of the valley. In that way, the basic architectural features of the Leshok house are formed. It is a typical mountain house built of stone and wood, on two floors and with an open veranda.
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