The Developmental Origin of Health and Disease (DOHaD) is an area of science dedicated to studying the processes by which insults during critical periods of mammals development leading to physiological changes resultig in diseases throughout life. Studies point to a complex interaction between nutritional status in early life and cardiovascular system homeostasis in which maternal malnutrition during gestation and/or lactation, as well as early weaning, are associated with development of cardiovascular diseases in adulthood. In this context, epigenetic c h a n g e s , s u c h a s D N A m e t h yl a t i o n , h i s t o n e acetylation, and change in microRNA expression have been considered molecular bases of cellular plasticity, which can also be gender-dependent. Experimental studies have demonstrated that interventions encompassing the consumption of functional food/bioactive compounds, as well as energetic and nutrients adjustments on the diet, may attenuate or even prevent consequences associated with plasticity of development, improving cardiovascular health. This review aimed to gather and discuss the findings within this context, published over the last ten years.
Background: During its commercialization phase, unprecedented effects of new medicaments can be discovered. Dabigatran is an anticoagulant approved by Brazilian National Health Surveillance Agency in 2008.
Atrial fibrillation (AF) is the most common type of sustained arrhythmia. The numerous gaps concerning the knowledge of its mechanism make improving clinical management difficult. As omics technologies allow more comprehensive insight into biology and disease at a molecular level, bioinformatics encompasses valuable tools for studying systems biology, as well as combining and modeling multi-omics data and networks. Network medicine is a subarea of network biology where disease traits are considered perturbations within the interactome. With this approach, potential disease drivers can be revealed, and the effect of drugs, novel or repurposed, used alone or in combination, may be studied. Thus, this work aims to review AF pathology from a network medicine perspective, helping researchers to comprehend the disease more deeply. Essential concepts involved in network medicine are highlighted, and specific research applying network medicine to study AF is discussed. Additionally, data integration through literature mining and bioinformatics tools, with network building, is exemplified. Together, all of the data show the substantial role of structural remodeling, the immune system, and inflammation in this disease etiology. Despite this, there are still gaps to be filled about AF.
No Brasil, espera-se que o docente de ensino superior seja formado nos programas de pós-graduação (PPG) stricto sensu nível mestrado e doutorado. Neste cenário, o estágio de docência permite que o pós-graduando seja introduzido aos saberes e práticas necessários à atuação profissional docente no ensino superior. Diante disso, o presente relato tem como objetivo analisar criticamente o papel do estágio de docência na formação pedagógica do pós-graduando. Utilizamos como base a experiência de um doutorando do PPG em Ciências Cardiovasculares da Universidade Federal Fluminense (UFF), autor deste relato. O estágio foi desenvolvido nos semestres letivos de 2022-1 e 2022-2, no retorno às aulas presenciais na UFF, após dois anos em ensino remoto emergencial. O estágio consistiu em aulas teóricas online que ocorreram concomitantemente ao acompanhamento de aulas presenciais na graduação sob supervisão. Com base nas atividades realizadas, discutimos o impacto do estágio de docência na construção do conceito de docência no ensino superior. Considerou-se a aplicação de conceitos teóricos na prática da sala de aula, as relações interpessoais e a dualidade pesquisa-ensino, assim como a formação docente do pós-graduando. Consideramos que para o pós-graduando é imprescindível a vivência do estágio de docência, porque ele promove reflexões sobre o fazer docente e permite a construção inicial dos saberes necessários à sua futura atuação como docente e pesquisador do ensino superior.
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