For biodegradable porous scaffolds to have a potential application in cartilage regeneration, they should enable cell growth and differentiation and should have adequate mechanical properties. In this study, our aim was to prepare biocompatible scaffolds with improved biomechanical properties. To this end, we have developed foam scaffolds from poly-Ɛ-caprolactone (PCL) with incorporated chitosan microparticles. The scaffolds were prepared by a salt leaching technique from either 10 or 15 wt% PCL solutions containing 0, 10 and 20 wt% chitosan microparticles, where the same amount and size of NaCl was used as a porogen in all the cases. PCL scaffolds without and with low amounts of chitosan (0 and 10 wt% chitosan) showed higher DNA content than scaffolds with high amounts of chitosan during a 22-day experiment. 10 wt% PCL with 10 and 20 wt% chitosan showed significantly increased viscoelastic properties compared to 15 wt% PCL scaffolds with 0 and 10 wt% chitosan. Thus, 10 wt% PCL scaffolds with 0 wt% and 10 wt% chitosan are potential scaffolds for cartilage regeneration.
Většina bakterií existuje jako komunita buněk adherujících k inertním i živým povrchům, toto mikrobiální společenství se nazývá biofilm. Biofilmy často souvisí s mnoha zdravotními problémy. Infekce vyvolané bakteriálním biofilmem jsou obzvláště problematické, protože přisedlé bakterie odolávají imunitním mechanismům hostitele a jsou extrémně odolné vůči antibiotikům a dezinfekcím. Přehledová práce se zabývá principem vzniku biofilmu a aspekty, které tento proces ovlivňují. Snaží se čtenářům přiblížit nové směry v moderním krytí ran, úpravě zdravotnických prostor, vody a invazivních zdravotnických prostředků, které by měly vést k minimalizaci vzniku biofilmu a výskytu infekcí spojených se zdravotní péčí.
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