Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.
This paper describes the synthesis and characterization of novel covalently bound fullerene ylidene malonate dyads in which the linker between the two units is a di-, tri-, or tetraethylene glycol unit. The synthesis involves a stepwise, convergent addition of the two components to bis(malonate crown ethers) of increasing overall dimensions through (i) Knoevenagel condensation with (dimethylamino)benzaldehyde and (ii) subsequent Bingel functionalization of the free malonate moiety with C 60 . These dyads have been spec- [a]
Solid-phase synthesis of 1H-benzo[d]imidazo[1,2-a]imidazol-2(3H)-one derivatives employing Fmoc-α-amino acids and nitroaryl fluorides as key building blocks has been developed. The Fmoc-α-amino acids immobilized on Wang resin, equipped with a piperazine carbamate linker, were transformed to o-nitroanilines in two steps. After reduction of the nitro group, the corresponding o-phenylenediamines gave the 2-aminobenzimidazole scaffold by reaction either with cyanogen bromide or with Fmoc-NCS. Cleavage from the polymer support and further cyclization afforded the target compounds. The developed methodology represents a versatile and simple approach for the preparation of various corresponding 1H-benzo[d]imidazo[1,2-a]imidazol-2(3H)-ones from a large number of commercially available building blocks.
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