Introduction Jr a is a high-frequency antigen belonging to the JR blood group system. Population studies have established that the Jr (a-) phenotype is rare. The clinical significance of anti-Jr a antibodies is controversial. This case report describes a newborn with prolonged jaundice due to alloimmunization against Jr a antigen. Case Outline A female Roma infant, 27 days of age, was admitted to hospital due to prolonged jaundice and failure to thrive. Immunohematological testing determined a blood group type A, D+ C+ E+ c+ e+, K-, and the presence of an antibody direct against a high-prevalence red blood cell antigens. On admission, total bilirubin was 199.6 μmol/l, direct bilirubin 10.3 μmol/l, hemoglobin concentration 132 g/l, hematocrit 41.1%, reticulocytes 1.08%. The newborn was the third child from a third routinely monitored pregnancy. Maternal sensitization to Jr a antigen was detected during the second pregnancy. The titer of anti-Jr a reached the highest value of 1,024 at the 28th week of gestation. Conclusion This is the first description of neonatal hyperbilirubinemia caused by anti-Jr a antibody in the Republic of Serbia. This case report provides new data about the clinical significance of anti-Jr a in pregnancy and the newborn.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.