Although prostate specific antigen is not a prostatic cancer specific parameter; the dynamics of its decrease during the therapy of androgen blockade represents a significant marker of the therapy effect.

An exact staging of clinical T3 stadium is usually difficult because of the frequent over and under staging. The risk prognostic stratification is performed through nomograms and ANN (artificial neural networks). The options for treatment are: radical prostatectomy, external radiotherapy and interstitial implantation of radioisotopes, hormonal therapy by androgen blockade. Radical prostatectomy is considered in patients with T3 stage but extensive dissection of lymph nodes, dissection of neurovascular bundle (on tumor side), total removal of seminal vesicle and sometimes resection of bladder neck are obligatory. Postoperative radiotherapy is performed in patients with invasion of seminal vesicles and capsular penetration or with prostate specific antigen value over 0.1 ng/ml, one month after the surgical treatment. Definitive radiotherapy could be used as the best treatment option considering clinical stage, Gleason score, age, starting prostate specific antigen (PSA) value, concomitant diseases, life expectancy, quality of life, through multidisciplinary approach (combined with androgen deprivation). Hormonal therapy in intended for patients who are not eligible for surgical treatment or radiotherapy. Conclusion Management of locally advanced prostate cancer is still controversial and studies fbr better diagnosis and new treatment modalities are ongoing.

Total androgen blockade and LH-RH agonists are more effective in lowering testosterone values (to castration values) compared to the antiandrogen monotherapy, where testosterone values stay above the castration level. This therapy approach has advantages, since it decreases testosterone values providing better therapy response. There is a difference in testosterone values, but not significant, when total androgen blockade and monotherapy with LH-RH agonists are administered. Registered lower basal values of LH in all patients with prostatic cancer open the possibility to introduce LH as a new additional, significant marker in diagnosis of this neoplasm.

Introduction. In recent years, there has been a growing global trend in the number of people with pathogens of sexually transmitted infections. There is a worldwide lack of data on the prevalence and incidence of sexually transmitted infections in the general population, especially among the high school students. Material and Methods. We conducted a cross sectional study on attitudes and knowledge of young people about sexually transmitted infections. The survey population included young people aged 14 to 20 years attending a high school in the city of Novi Sad. The data were collected through a questionnaire. Results. The percentage of students with signs and symptoms of sexually transmitted infections was higher among the students who did not use a condom during the last sexual intercourse compared to the students who used a condom. Conclusion. Young people engaging in risky sexual behavior showed better knowledge about sexually transmitted infections in comparison to young people who did not engage in risky sexual behavior.