Aims Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma‐1 receptor agonist, has so far shown promise in the prevention of COVID‐19 progression as an early treatment option in three trials. The aim of this study was to evaluate the safety and efficacy of fluvoxamine in COVID‐19 patients if administered later in the course of the disease. Methods The study was designed as an open‐label, prospective cohort trial with matched controls. In April and May 2021, 51 ICU COVID‐19 patients hospitalised in the University Hospital Dubrava and University Hospital Centre Zagreb, Croatia, were treated with fluvoxamine 100 mg three times daily for 15 days in addition to standard therapy and they were prospectively matched for age, gender, vaccination against COVID‐19, disease severity and comorbidities with 51 ICU controls. Results No statistically significant differences between groups were observed regarding the number of days on ventilator support, duration of ICU or total hospital stay. However, overall mortality was lower in the fluvoxamine group, 58.8% ( n = 30/51), than in the control group, 76.5% ( n = 39/51), HR 0.58, 95% CI (0.36–0.94, P = .027). Conclusion Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID‐19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID‐19 patients are urgently required.

In the Central Dinarides and South Tisia different Paleozoic complexes occur in four geotectonic zones: (1) comparatively autochthonous units located in the cores of disrupted anticlines of the External Dinarides; (2) allochthonous disrupted units accompanied by more predominant Triassic formations in the Sava Nappe, which is thrust onto the northeastern margin of the External Dinarides; (3) allochthonous disrupted units, also together with Triassic formations, in the Pannonian and Durmitor nappes of the Internal Dinarides; and (4) polymetamorphic sequences in basement of the Pannonian Basin and South Tisia, respectively. This paper presents basic geological features for the main Paleozoic areas included in these four zones. The tectonostratigraphic units of the first two zones were related to the Gondwana passive continental margin, those of the third zone to the Paleotethyan oceanic realm, and those of Tisia to the active Laurussia margin. Geodynamic evolution of all these Paleozoic complexes was related to opening and closure of the Rheic and Paleotethys Oceans. Rifting processes along North Gondwana started in the Silurian, locally in the Cambrian-Ordovician, and were followed by the Late Silurian/Devonian opening of the Paleotethys. Subduction processes were active by the end of the Devonian and at the beginning of the Carboniferous along the Laurussia margin. They were followed during the Westphalian by main Variscan deformation during collision of Gondwana and Laurussia. Associated metamorphism was very low-grade in the Paleozoic units of the Sava Nappe, low-grade to epidote-amphibolite grade within the Paleozoic complexes of the Pannonian and Durmitor nappes in the Internal Dinarides, and polymetamorphic with migmatites and granitoids in South Tisia. These processes gave rise to a Pangea stage with the Variscan basement disconformably overlain by Late Carboniferous and Permian sediments.

The Grohovo landslide is the largest active slope movement along the Croatian coast, situated on the north-eastern slope in the central part of the Rječina River Valley (north-eastern coastal part of Adriatic Sea, Croatia). Slopes in this valley are formed of siliciclastic rocks (i.e., fl ysch), while the limestone rock mass is visible on the cliffs around the top of the river valley. The slopes are at the limit of a stable equilibrium state, and slope movement phenomena have been recorded since the 19th century. Samples for laboratory testing were taken from the fl ysch bedrock, weathered zone and slope deposits to provide specimens for determination of their mineralogical, physical and geotechnical properties. Correlation between mineralogical and geotechnical properties and their infl uence on sliding processes are presented here. The clay fraction in samples ranges from 17 % to 38 %. Clay activity of the tested samples is from 0.45 to 0.89, and the residual friction angle varies from 13.0° to 17.7°. These results correspond to the presence of kaolinite and illite groups of clay mineral. Both the mineral composition and decrease in strength of fi ne-grained soil materials, due to the increase of pore water pressures, contributes to slope movements.

A 20-year-old woman presented with nasal obstruction and slight epistaxis. The obstructing lesion was excised and microscopy showed a neoplasm composed of comparatively uniform undifferentiated cells forming solid nests. The cytoplasm of the cells was clear but poorly demarcated, partly vacuolated and contained much glycogen. Although widespread in the nasal mucosa, the cells did not penetrate into the underlying bone. The cells expressed the MIC2 gene (using the CD99 marker). Electron microscopy showed simple cells with a small number of mitochondria, many glycogen particles; there were no neurosecretory granules present. Early surgical treatment followed by chemo- and radiotherapy have greatly improved the prognosis of EWS: extraskeletal Ewing's sarcoma (EWS/PNET).

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