Dimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, 1H, and 31P NMR spectroscopy. In vitro HL1 and HL2 at 1 mM concentration caused cell specific and time-dependent decrease of leukemic cell viability. Compounds caused the similar gradual decrease of Jurkat cells viability at 72 h (by 35%). HL1 had earlier and more profound toxic effect as compared to HL2 regardless on leukemic cell line. Viability of Molt-16 and CCRF-CEM cells under the action of HL1 was decreased at 24 h (by 32 and 45%, respectively) with no substantial further reducing up to 72 h. Toxic effect of HL2 was detected only at 72 h of incubation of Jurkat and Molt-16 cells (cell viability was decreased by 40 and 45%, respectively).It was shown that C60 fullerene enhanced the toxic effect of HL2 on leukemic cells. Viability of Jurkat and CCRF-CEM cells at combined action of C60 fullerene and HL2 was decreased at 72 h (by 20 and 24%, respectively) in comparison with the effect of HL2 taken separately.In silico study showed that HL1 and HL2 can interact with DNA and form complexes with DNA both separately and in combination with C60 fullerene. More stable complexes are formed when DNA interacts with HL1 or C60 + HL2 structure. Strong stacking interactions can be formed between HL2 and C60 fullerene. Differences in the types of identified bonds and ways of binding can determine distinction in cytotoxic effects of studied compounds.
The cubic crystal structure of the title compound, [NaNd(C14H21N3O5PS)4]n, is composed of one-dimensional polymeric chains propagating in [100], built up from [Nd(C14H21N3O5PS)4]− anions and sodium cations functioning as linkers. In the complex anion, the Nd3+ ion has an eightfold coordination environment formed by the sulfonyl and phosphoryl O atoms of four bidentate chelating N-(dimorpholinophosphoryl)benzenesulfonamidate ligands: the resulting NdO8 polyhedron can be described as intermediate between dodecahedral and square antiprismatic. The sodium ion adopts an NaO4 tetrahedral geometry arising from four monodentate benzenesulfonamidate ligands. The resulting crystal structure is unusual because it contains substantial voids (800 Å3 per unit cell), within which there is no evidence of included solvent.
In the title compound, three ligands are coordinated to the Ca2+ ion in a bidentate-chelated manner via the O atoms of the CO and PO groups. The sodium ion is encapsulated between three chelated metallacycles {CaL}(where L
− = Cl3CC(O)NP(O)[N(C2H5)2]2) due to the bridging function of the carbonyl O atoms and it is capped by the water molecule.
The title compound, C4H6N3OS+·H2PO4
−, (I), was obtained as a result of hydrolysis of [(1,3-thiazol-2-ylamino)carbonyl]phosphoramidic acid, (II), in water. X-ray analysis has shown that the N—P bond in (II) breaks, leading to the formation of the substituted carbamide (I). This compound exists as an internal salt. The unit cell consists of a urea cation and an anion of H2PO4
−. Protonation of the N atom of the heterocyclic ring was confirmed by the location of the H atom in a difference Fourier map. The molecules of substituted urea are connected by O⋯O hydrogen bonds into unlimited planes. In turn, those planes are connected to each other via N—H⋯O hydrogen bonds with molecules of phosphoric acid, forming a three-dimensional polymer.
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