The idea that the effects of drugs largely depend on subcellular target location is emerging as a novel predictive factor of their beneficial or adverse outcomes. G protein-coupled type-1 cannabinoid receptors (CB 1 ) are regulators of several brain functions as well as the main targets of cannabinoid-based medicines.Besides their classical location at plasma membranes, CB 1 receptors are present at different locations within cells, including in association to mitochondrial membranes (mtCB 1 ). Here we report the generation and characterization of a mutant mouse line, which lack mtCB 1 receptors.
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