No abstract

Addition of benzenesulfenyl chloride to electron-rich olefins in the presence of silver produces /3-fluoro thioethers. The trans adducts could also be prepared from d-chloro thioethers and silver fluoride.

SummarySyntheses of labelled versions of 5-HT3 receptor antagonists, Alosetron and Lurosetron, are described. [14C]Alosetron was prepared by routes utilizing either Fischer indolisation of an amidohydrazine or palladium-mediated cyclisation of an aryl enaminone as key steps. 2H and 13C versions of Alosetron were prepared from suitably labelled imidazoles.Lurosetron was labelled in either the methylene bridge carbon or carbonyl carbon, using 14C-labelled paraformaldehyde or phosgene, respectively.

Die Cyclohexene (I) addieren Phenylsulfenylchlorid (II) in Gegenwart von AgF zu den Fluor‐thioethern (III), während aus (Ia) mit KF die Chlorverbindung (IV) erhalten wird.