A new class of anion selective receptors is based on the neutral
uranylsalophene building block as
Lewis acidic binding site. Additional hydrogen bond accepting or
donating moieties near the anion
binding site offer the possibility of varying the binding selectivity.
Field effect transistors chemically
modified with such receptors exhibit anion selectivities that strongly
deviate from the classical
Hofmeister series favoring phosphate or fluoride anions, depending on
the structure of the
uranylsalophenes. The phosphate selective chemically modified
field effect transistors (CHEMFETs)
detect phosphate with high selectivity over much more lipophilic
anions, such as nitrate (log
= −1.3), at [H2PO4
-] ≥ 6.3
× 10-4 M. CHEMFETs modified with
salophenes with amido
substituents result in a high fluoride selectivity; even in the
presence of 0.1 M chloride, fluoride
can be detected at [F-] ≥ 6 × 10-4 M
(log
= −2.0).
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