Brief Reports should be submitted online to www.editorialmanager.com/ amsurg. (See details online under ''Instructions for Authors''.) They should be no more than 4 double-spaced pages with no Abstract or sub-headings, with a maximum of four (4) references. If figures are included, they should be limited to two (2). The cost of printing color figures is the responsibility of the author.
Aim:The aim of this study was to assess the efficacy of preoperative axillary ultrasonography (AUS) and preoperative axillary fine-needle aspiration biopsy (FNAB) from suspicious lymph nodes in clinically node-negative breast cancer to compare with radiologically positive and sentinel lymph node biopsy (SLNB) positive involvement.Method: Clinically node-negative early-stage breast cancer patients were included in the study. These patients underwent preoperative AUS examination, suspicious lymph nodes were evaluated with FNAB. AUS-FNAB results were compared with those of SLNB or axillary dissection.Results: Of 181 patients undergoing AUS, 32 were reported to have axillary metastasis, 25 suspicious, and 124 benign nodes. The suspicious group underwent FNAB examination and metastasis was found in 9 of them. The sensitivity of AUS-FNAB was found to be 64.06%, specificity 100%, positive predictive value 100%, and negative predictive value (NPV) 83.5%. The false negativity rate (FN) of this method was 16,4%. Lymphovascular invasion and tumour size were found statistically significant factors for false negativity.
Conclusion:It was concluded that axillary AUS-FNAB with its high NPV, low FN rate, may be a clinical alternative to SLNB for early-stage breast cancer patients. How to cite this article: Özler İ, Aydin H, Güler OC, et al. Can preoperative axillary ultrasound and biopsy of suspicious lymph nodes be an alternative to sentinel lymph node biopsy in clinical node negative early breast cancer?. Int J Clin Pract.
Aim: The aim of this study was to assess the efficacy of pre-operative
axillary ultrasonography (AUS) and pre-operative axillary fine-needle
aspiration biopsy (FNAB) from suspicious lymph nodes in clinically
node-negative breast cancer to compare with radiologically positive and
sentinel lymph node biopsy (SLNB) positive involvement. Method:
Clinically node-negative early-stage breast cancer patients were
included in the study. These patients under went pre-operative AUS
examination, suspicious lymph nodes were evaluated with FNAB. AUS-FNAB
results were compared with those of SLNB or of axillary dissection.
Results: Of 181 patients undergoing AUS, 32 were reported to have
axillary metastasis, 25 suspicious and 124 benign nodes. The suspicious
group underwent FNAB examination and metastasis was found in 9 of them.
The sensitivity of AUS-FNAB was found to be 64.06%, specificity 100%,
positive predictive value 100% and negative predictive value (NPV)
83.5%. False negativity rate (FN) of this method was 16,4%.
Lymphovascular invasion and tumor size were found statistically
significant factors for false negativity. Conclusion:It was concluded
that axillary AUS-FNAB with its high NPV, low FN rate, may be a clinical
alternative to SLNB for early stage breast cancer patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.