Background: Cyclooxygenase-2 (COX-2) levels increase in women with endometriosis. COX-2, via increasing prostaglandin E2, contributes to an increase in vascular endothelial growth factor. In this way, COX-2 may contribute to the progression and continuity of endometriosis. We investigated the effect of dexketoprofen trometamol, a new selective COX-2 enzyme inhibitor, on experimentally induced endometriotic cysts. Methods: Experimental endometriotic cysts were created in 60 adult female Wistar albino rats. The rats were randomized to 2 equal groups, a control (group Con) and a dexketoprofen (group Dex) group. Six weeks later, cyst volumes were measured as in vivo (volume 1). Following volume 1 measurement, for 4 weeks group Con received 0.1 ml distilled water; group Dex received 0.375 mg dexketoprofen trometamol/0.1 ml distilled water, intramuscularly, twice a day. At the end of administration, the cyst volumes were remeasured (volume 2), and the cysts totally excised and weighed. Glandular (GT) and stromal tissues (ST) and natural killer (NK) cell contents in the cyst wall were scored. Results: NK cell content and volume 1 were not different between the 2 groups. Volume 2, cyst weight, and GT and ST contents in group Dex were significantly lower than those in group Con. Conclusion: Dexketoprofen trometamol significantly reduced the development of experimentally induced endometriotic cysts both macroscopically and microscopically.
Objective The aim of this study was to report the morbidity and mortality rates associated with hysterectomies performed at our unit and to recommend a plan to reduce complications. Methods: In this retrospective review of morbidity and mortality rates, we reviewed the charts of 1188 patients who underwent hysterectomy between 1999 and 2008 at the Ondokuz Mayis University Hospital in Samsun, Turkey. Results The overall hysterectomy-related morbidity rate was 4.3%. There were no operative or postoperative deaths. The incidence of intraoperative bowel injury was 0.4%, bladder injury was 0.5%, while the incidence of vesicovaginal fistula was 0.2% in this study. Conclusions In order to reduce the hysterectomy-related morbidity rate, proper selection, pre-operative preparation and less invasive alternative treatments can be employed, such as various methods of endometrial ablation or resections. (Journal of Endometriosis 2010; 2: 41–4)
The magnitude of the elevation is important and levels > 200 U/ml are potentially associated with ovarian malignancies, whereas slight increases in levels were associated with benign gynecologic conditions. However, serum CA-125 levels > 1000 U/ml have also been reported in patients with endometriosis. Herein, the authors report an additional case of high levels of CA-125 in large unruptured endometrioma. We present a patient with moderate sized bilateral ovarian endometrioma who was undergoing laparotomy and who had CA-125 levels of 3782 U/mL. Our case further emphasizes that very high levels of CA-125 are not always associated with malignant disease and no critical cutoff value for CA-125 is diagnostic of malignancy.
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