Intervalley carrier transfer in short-wavelength InP-based quantum-cascade laser Appl. Phys. Lett. 93, 071109 (2008); 10.1063/1.2973212 Short-wavelength ( λ ≈ 3.05 μ m ) InP-based strain-compensated quantum-cascade laser Appl. Phys. Lett. 90, 051111 (2007); 10.1063/1.2437108 Short-wavelength ( λ ≈ 3.3 μ m ) InP-based strain-compensated quantum-cascade laserThe effect of doping concentration on the performance of short-wavelength quantum-cascade lasers based on the strain-compensated InGaAs/InAlAs/AlAs heterostructure on InP, emitting at 3.8 m, is investigated for average doping concentrations between 0.3 and 3.9ϫ 10 17 cm −3 ͑sheet densities between 1.6 and 20.9ϫ 10 11 cm −2 ͒. Although the threshold current density is rather independent of doping concentration, the maximum current density increases with doping and exhibits a saturation for the highest doping level. Other important performance characteristics such as differential quantum efficiency, peak optical emission power, slope efficiency, and maximum operating temperature are observed to be maximized for structures with an average doping of 2 − 3 ϫ 10 17 cm −3 , corresponding to a sheet density of about 1.5ϫ 10 12 cm −2 .

The purpose of this study is to assess the feasibility of using breath ammonia analysis based on off-axis cavity-enhanced absorption spectroscopy (OA-CEAS) with an external-cavity diode laser (ECL) for noninvasive, real-time diagnosis of Helicobacter pylori (HP) infection. Analyses are performed for the breath of 15 healthy volunteers, and eight children and 19 adults with HP infection. The range of ammonia levels for healthy participants is determined to be between 178 and 610 ppb, whereas the ranges for child and adult patients with HP infection are measured to be 457-2470 ppb and 450-2990 ppb, respectively. The ammonia concentrations for patients with HP infection are significantly higher than the concentrations for healthy volunteers. However, no sharp boundary between the ammonia concentrations in the breath of patients with HP infection and healthy volunteers is observed. No correlation between breath ammonia and either body mass index (BMI) or age is found. The reported results suggest that our breath ammonia measurement system has the potential for future use in easy, noninvasive diagnosis of HP infection.

A robust biomedical sensor for ultrasensitive detection of biomarkers in breath based on a tunable external cavity laser (ECL) and an off-axis cavity-enhanced absorption spectroscopy (OA-CEAS) using an amplitude stabilizer is developed. A single-mode, narrow-linewidth, tunable ECL is demonstrated. A broadly coarse wavelength tuning range of 720 cm⁻¹ for the spectral range between 6890 and 6170 cm⁻¹ is achieved by rotating the diffraction grating forming a Littrow-type external-cavity configuration. A mode-hop-free tuning range of 1.85 cm⁻¹ is obtained. The linewidths below 140 kHz are recorded. The ECL is combined with an OA-CEAS to perform laser chemical sensing. Our system is able to detect any molecule in breath at concentrations to the ppbv range that have absorption lines in the spectral range between 1450 and 1620 nm. Ammonia is selected as target molecule to evaluate the performance of the sensor. Using the absorption line of ammonia at 6528.76 cm⁻¹, a minimum detectable absorption coefficient of approximately 1×10⁻⁸ cm⁻¹ is demonstrated for 256 averages. This is achieved for a 1.4-km absorption path length and a 2-s data-acquisition time. These results yield a detection sensitivity of approximately 8.6×10⁻¹⁰ cm⁻¹ Hz(-1/2). Ammonia in exhaled breath is analyzed and found in a concentration of 870 ppb for our example.

Most techniques that are used for diagnosis and therapy of diseases are invasive. Reliable noninvasive methods are always needed for the comfort of patients. Owing to its noninvasiveness, ease of use, and easy repeatability, exhaled breath analysis is a very good candidate for this purpose. Breath analysis can be performed using different techniques, such as gas chromatography mass spectrometry (MS), proton transfer reaction-MS, and selected ion flow tube-MS. However, these devices are bulky and require complicated procedures for sample collection and preconcentration. Therefore, these are not practical for routine applications in hospitals. Laser-based techniques with small size, robustness, low cost, low response time, accuracy, precision, high sensitivity, selectivity, low detection limit, real-time, and point-of-care detection have a great potential for routine use in hospitals. In this review paper, the recent advances in the fields of external cavity lasers and breath analysis for detection of diseases are presented.

Quantum-cascade lasers operating at λ≈3.9μm at room temperature with narrow w≈5μm ridge widths are described. The lateral confinement due to the narrow ridge is similar to the vertical confinement and the resulting beam is circular in cross section with a single TM00 spatial mode. The beam divergence is 46° both parallel and perpendicular to the surface. The beam quality factor along the slow axis is about M2=1.6. The narrow ridges also increase the relative lateral heat dissipation from the active region, resulting in a thermal conductance per unit area of about Gth=380WK−1cm−2 for a 3mm long laser. Maximum average power is obtained with duty cycles between 10% and 30%; in spite of the very narrow ridge, the total average power with thermoelectric cooling exceeds 60mW with a peak power of 460mW. The circularly symmetric beam with very good beam quality suggests essentially zero astigmatism and indicates that these narrow-ridge quantum-cascade lasers are well suited for applications in midinfrared spectroscopy and imaging.