Theobromine
molecules and related compounds such as caffeine and
theophylline are of importance for pharmacology, toxicology, and biochemistry.
In this field, it is fundamental to study the emergence of chirality.
Chirality can emerge because of surface adsorption. Therefore, it
is necessary to study the chiral adsorption of theobromine on the
surface. Here, we present the first experimental comparative study
of theobromine monolayers on Au(111) and on few-layer graphene on
SiC(0001). The self-assembly of theobromine is characterized utilizing
scanning tunneling microscopy and low-energy electron diffraction.
Additionally, simulations with LEEDpat are performed and compared
with the experimental data. We found that the adsorbate unit cell
is rectangular and consists of four molecules. Theobromine shows geometrically
similar unit cells on both substrates. On Au(111), the molecules are
prochiral, with two enantiomers in a zig-zag structure, which is explained
by glide reflections.
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