A fluorescent
2,1,3-benzothiadiazole-containing goniothalamin derivative,
BTD−GTN (1), has been synthesized and successfully
tested in bioimaging experiments in live cells. The fluorescent compound
proved to be capable of transposing the cell membranes, indicating
its subcellular localization. The use of the benzothiadiazole core
as the fluorophore revealed the favored localization of the GTN analogue 1 in the cytoplasm of live cells, preferentially in the mitochondria,
in line with previous results that indicated the loss of mitochondrial
transmembrane potential upon treatment with GTN. The results described
herein highlight the potential of the BTD–GTN hybrid structures
for future studies regarding the cellular mechanism of action of this
family of compounds.
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