Sepsis, still cause morbidity and mortality in children admitted to the pediatric intensive care unit (PICU). Several diagnostic and biological markers have y been studied to monitor unfavorable evolution of sepsis in critically ill patients but didn’t established. Objective: This study aimed to evaluate the Left ventricle ejection fraction, serum Ferritin and C - reactive protein and find out their value as early prognostic markers for outcomes in pediatric sepsis in PICU. Patients and Methods: 40 patients admitted to a PICU diagnosed with sepsis. Echocardiography study: to figure out the ejection fraction (EF) of the left ventricle, serum levels of C-reactive protein and ferritin on D1 and D3 after admission. Patients followed to detect their outcomes and mortality. Results: We found with cardiac dysfunction by echocardiogram and elevated ferritin levels on D1 had longer hospital stay in, prolonged duration of mechanical ventilation use, higher maximum inotropic score, and fewer ventilator-free hours. Both low Left ventricle ejection fraction and high serum Ferritin are associated with unfavorable outcomes. Conclusion: Cardiac dysfunction by echocardiogram (EF < 55%) and serum ferritin values (≥300 ng/mL) on D1 of admission in pediatric patients with sepsis admitted to the PICU, were significantly associated with unfavorable outcomes.
Introduction:Sepsis is a life threatening condition which affects many children, Sepsis is said to be one of the leading causes of death among children even in advanced countries. Aim of the work: to verify the association between cardiac dysfunction and serum ferritin level with unfavorable outcomes in pediatric sepsis. Patients and Methods: This prospective cohort study was carried out on 40 patients with suspected or confirmed sepsis in our PICU. All patients in the study were subjected for assay of serum levels of ferritin, CRP and echocardiography on Day of admission & Day 3. Results: Serum Ferritin level was significantly higher among cases with cardiac dysfunction than cases without cardiac dysfunction. There was highly statistically significant difference between day of admission D1 and third day as regard to serum ferritin level and CRP with median value of Ferritin level and CRP were higher on the day of admission compared to third day.
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