formed according to Interchim (Interchim, Inc., San Pedro, CA) recommendations. 3 All samples were then analyzed using an ultraviolet-visible spectrophotometer (Shimadzu UV-2401PC; Shimadzu, Columbia, MD) at a wavelength of 412 nm.Results and Discussion. Results indicated that mesna concentrations in the ReadyMed infusion devices were maintained within acceptable limits (110-90%), relative to their original concentrations, over a period of 28 days when stored at 5˚C and 14 days when stored at 25˚C ( Figure 1). Our results were consistent with those of Goren et al., 4 who reported on the stability of mesna in polypropylene syringes at 5˚C, 24˚C, and 35˚C and those of Menard et al., 5 who studied the stability of cyclophosphamide and mesna mixtures in polyethylene infusion bags of 5% dextrose.In order to elucidate the effect of EDTA on the stability of mesna, a separate study was conducted in which a fresh mesna solution was prepared by weighing pure mesna (Fluka, St. Louis, MO) and mixing it with water to make a solution at 100 mg/mL. Then this solution was further diluted with 5% dextrose solution to lower the mesna concentration to 10 mg/mL. The solution was stored in a vial at 25˚C and was analyzed as described in the Methods section. The stability profile of this mesna solution followed a first-order degradation pattern (data fitted to first-order function; Figure 1). The rate constant of degradation was 0.023 h -1 , which corresponds to a shelf life (t 90 ) of 4.56 hours. This study explained why the presence of EDTA has a positive influence on the stability of mesna.Mesna solutions in ReadyMed devices were stable for 14 days at 25˚C and for 28 days at 5˚C when a commercialized product of mesna stabilized with EDTA (0.25 mg/mL) was mixed at a ratio of 1:10 with 5% dextrose solution. Our second stability study of mesna indicated that the shelf life could be significantly shortened with the absence of EDTA. .1M390 significant drug-drug interaction between clopidogrel and PPIs. Recommending a specific PPI is premature and there are conflicting data as to whether one PPI is less likely to interact with clopidogrel than another and whether there actually is a drug-drug interaction at all.
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