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The synthesis of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)amino-4-(2,4 dichlorophenyl)thiazol-5-yl-diazenyl)phenyl is reported in this work with a detailed structural and molecular docking study on two SARS-COV-2 proteins: 3TNT and 6LU7. The studied compound has been synthesized by the condensation of cyanuric chloride with aniline and characterized with various spectroscopic techniques. The experimentally obtained spectroscopic data has been compared with theoretical calculated results achieved using high-level density functional theory (DFT) method. Stability, nature of bonding, and reactivity of the studied compound was evaluated at DFT/B3LYP/6-31 + (d) level of theory. Hyper-conjugative interaction persisting within the molecules which accounts for the bio-activity of the compound was evaluated from natural bond orbital (NBO) analysis. Adsorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) properties of the experimentally synthesized compound was studied to evaluate the pharmacological as well as in silico molecular docking against SARS-CoV-2 receptors. The molecular docking result revealed that the investigated compound exhibited binding affinity of −9.3 and −8.8 for protein 3TNT and 6LU7 respectively. In conclusion, protein 3TNT with the best binding affinity for the ligand is the most suitable for treatment of SARS-CoV-2.

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Reactive disperse dyes containing monochlorotriazine/sulphatoethylsulphone reactive moieties were synthesized by condensing aniline with cyanuric chloride and further reacting it with a series of monoazo dyes obtained by diazotising 1-aminobenzene-4-β-sulphatoethylsulphone and coupling with various substituted 2-amino-4-phenylthiazole derivatives. The dyeing performance of the dyes was evaluated on polyester and wool fabrics. The dyes obtained gave various shades ranging from reddish to bright red colours. They had good depth and good levelling properties. They dyed fabrics showed moderate to good light fastness properties and very good to excellent fastness to washing and perspiration. The dye bath exhaustion on the polyester and wool fabrics were found to be very good and their fixation values were moderate.