The kinetics of oxidation of chondroitin-4-sulfate as sulfated carbohydrates by alkaline permanganate has been investigated spectrophotometrically. The oxidation reaction was found to proceed through two-distinct stages. The first stage was found to be relatively fast involving the formation of unstable green [CS, MnVIO42-] and blue [CS, MnVO43-] biopolymeric coordination intermediates at wavelengths of 610 and 730 nm, respectively. The second stage was corresponding to a slow decomposition of such intermediates to give rise to keto-acid derivative and soluble-colloidal manganese (IV) as final oxidation products. The oxidation reaction was found to be base-catalyzed. The kinetic parameters have been evaluated and a tentative oxidation reaction mechanism in good consistent with the kinetic results was suggested and discussed. Novel keto-acid derivative has been synthesized. The reaction product was characterized and identified by elemental analysis and spectral data
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.