The present review article describes the recent developments (2014–18) on the synthesis of ferrocene-based pharmacophores with the specific benefits of introducing/replacing organic pharmacophores with the ferrocene core for desired bioactivities.

Recent developments in synthetic strategies towards functionalized azetidines along with their versatility as heterocyclic synthons.

The synthesis and characterization of mononuclear [Cu(L) 2 -(Cl) 2 ] (1), dinuclear [{CuCl(L)} 2 (μ-Cl) 2 ] (2), and another mononuclear complex [Cu(L) 2 (ClO 4 ) 2 ] (3) with a bidentate N,Ndiisopropylpicolinamide ligand (abbreviated L) are described. Complexes 1 and 2 were obtained from the same reaction mixture and show thermo-and solvatochromic behavior. Complex 1 shows irreversible thermochromism by changing into 2 upon heating at 160°C. These two complexes also show solvatochromism in various solvents. The[a]

The Cu(II)-catalyzed oxidative and reductive cleavage of the disulfide bond of N-(2-(2-(2-picolinamido)phenyl)disulfanyl)phenyl)picolinamide, L, is reported for the first time. Aerobic oxidation with Cu(II) gives complete oxidation of S-S bond to sulfonates, whereas Ag(I) gives only partial oxidation up to sulfinates, in the absence of any other oxidizing agent, in tetrahydrofuran/water solution. The in situ generated sulfonate product forms a thermally stable, two-dimensional H-bonded polymeric complex with Cu(II) ions in two polymorphic forms. L in the presence of Cu(II), in an inert atmosphere, results in a reductive cleavage of the disulfide bond and an in situ formation of a new C-S bond. The latter forms a unique tetranuclear complex with Cu(II) employing deprotonated amide groups and bridging thiol and chloride atoms. The disulfide precursor and the products were characterized by X-ray crystallography and spectroscopic techniques.

Correction for ‘Ferrocene-appended pharmacophores: an exciting approach for modulating the biological potential of organic scaffolds’ by Amandeep Singh et al., Dalton Trans., 2019, DOI: 10.1039/c8dt03440k.

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